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【结 构 式】 
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【分子编号】58404 【品名】[(2R,3S,5S)-5-(diisopropoxyphosphoryl)-3-hydroxytetrahydro-2-furanyl]methyl methanesulfonate 【CA登记号】 |
【 分 子 式 】C12H25O8PS 【 分 子 量 】360.365462 【元素组成】C 40% H 6.99% O 35.52% P 8.6% S 8.9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The condensation between mesylate (I) and 2-amino-6-chloropurine (II) in the presence of Cs2CO3 affords nucleoside (III). Hydrolysis of (III) with trimethylsilyl bromide, followed by refluxing with HCl, provides the target phosphonic acid, which is finally isolated as the corresponding ammonium salt.
| 【1】 Chan, L.; Nghe, P.; Vaillancourt, L.; Bubenik, M.; Novel antineoplasic phosphonate nucleosides. 223rd ACS Natl Meet (April 7 2002, Orlando) 2002, Abst MEDI 207. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 58404 | [(2R,3S,5S)-5-(diisopropoxyphosphoryl)-3-hydroxytetrahydro-2-furanyl]methyl methanesulfonate | C12H25O8PS | 详情 | 详情 | |
| (II) | 11644 | 6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine | 10310-21-1 | C5H4ClN5 | 详情 | 详情 |
| (III) | 58405 | diisopropyl (2S,4S,5R)-5-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-4-hydroxytetrahydro-2-furanylphosphonate | C16H25ClN5O5P | 详情 | 详情 |
Extended Information