N-((1S)-1-{[((1S,2S)-3-{[(1S)-2-amino-1-(4-bromobenzyl)-2-oxoethyl]amino}-1-benzyl-2-hydroxypropyl)amino]carbonyl}-2-methylpropyl)-2-pyridinecarboxamide -Drug Synthesis Database

【结构式】

【分子编号】58403

【品名】N-((1S)-1-{[((1S,2S)-3-{[(1S)-2-amino-1-(4-bromobenzyl)-2-oxoethyl]amino}-1-benzyl-2-hydroxypropyl)amino]carbonyl}-2-methylpropyl)-2-pyridinecarboxamide

【CA登记号】

【分子式】C₃₀H₃₆BrN₅O₄

【分子量】610.55114

【元素组成】C 59.02% H 5.94% Br 13.09% N 11.47% O 10.48%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XI)

The N-carbobenzoxy group of (X) is then removed by treatment with triflic acid, yielding (XI). Finally, Suzuki coupling of the aryl bromide (XI) with phenylboronic acid leads to the title biphenyl derivative.

参考文献中间体

合成目标

【1】 Noteberg, D.; et al.; New antimalarials: Design and synthesis of protease inhibitors with effect in cultured parasite-infected human erythrocytes. Drugs Fut 2002, 27, Suppl. A.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(X)	58401	benzyl (1S)-2-amino-1-(4-bromobenzyl)-2-oxoethyl[(2S,3S)-2-hydroxy-3-({(2S)-3-methyl-2-[(2-pyridinylcarbonyl)amino]butanoyl}amino)-4-phenylbutyl]carbamate		C₃₈H₄₂BrN₅O₆	详情	详情
(XI)	58403	N-((1S)-1-{[((1S,2S)-3-{[(1S)-2-amino-1-(4-bromobenzyl)-2-oxoethyl]amino}-1-benzyl-2-hydroxypropyl)amino]carbonyl}-2-methylpropyl)-2-pyridinecarboxamide		C₃₀H₃₆BrN₅O₄	详情	详情

Extended Information