2-methyl-6-nitro-4-quinolinecarboxamide -Drug Synthesis Database

【结构式】

【分子编号】58317

【品名】2-methyl-6-nitro-4-quinolinecarboxamide

【CA登记号】

【分子式】C₁₁H₉N₃O₃

【分子量】231.21088

【元素组成】C 57.14% H 3.92% N 18.17% O 20.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

5-Nitroisatin (VIII) is condensed with acetone in the presence of aqueous ammonia in an autoclave at 100 C to produce the quinolinecarboxamide (IX). Subsequent Hofmann rearrangement of (IX) with sodium hypochlorite produces the 4-amino quinoline (X). The nitro group of (X) is then reduced by catalytic hydrogenation over Pd/C to give the diaminoquinoline (VII).

参考文献中间体

合成目标

【1】 Shinkai, H.; Yamada, H.; to, T. (Japan Tobacco Inc.); Amide derivs. and nociceptin antagonists. EP 1072263; JP 1999335355; WO 9948492 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VII)	58318	2-methyl-6-nitro-4-quinolinamine; 2-methyl-6-nitro-4-quinolinylamine		C₁₀H₉N₃O₂	详情	详情
(VIII)	49031	4-amino-2-methyl-6-quinolinylamine; 2-methyl-4,6-quinolinediamine		C₁₀H₁₁N₃	详情	详情
(IX)	58316	5-nitro-1H-indole-2,3-dione; 5-Nitroisatin	611-09-6	C₈H₄N₂O₄	详情	详情
(X)	58317	2-methyl-6-nitro-4-quinolinecarboxamide		C₁₁H₉N₃O₃	详情	详情

Extended Information