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【结 构 式】 
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【分子编号】58313 【品名】 【CA登记号】 |
【 分 子 式 】C12H18O6 【 分 子 量 】258.27132 【元素组成】C 55.81% H 7.02% O 37.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The epoxidation of the octadienamide intermediate (I) (scheme no. 26150102b, intermediate (XXIV)) by means of ketone (II), Oxone, Bu4N HSO4 and Na2-EDTA in acetonitrile/water gives the epoxide (III), which is condensed with the pentanoic acid (IV) by means of DCC and DMAP in dichloromethane to yield the ester (V). Finally, this compound is deprotected and submitted to macrocyclization by means of piperidine in DMF to afford the target Cryptophycin 52.
| 【1】 Hoard, D.W.; et al.; Synthesis of cryptophycin 52 using the shi epoxidation. Org Lett 2002, 4, 10, 1813. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18905 | 2,2,2-trichloroethyl (2R)-3-(3-chloro-4-methoxyphenyl)-2-[[(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl]amino]propanoate | C27H29Cl4NO5 | 详情 | 详情 | |
| (II) | 58313 | C12H18O6 | 详情 | 详情 | ||
| (III) | 58514 | N-(5-chloro-2-methoxyphenyl)-3,5-bis(trifluoromethyl)benzamide | C16H10ClF6NO2 | 详情 | 详情 | |
| (IV) | 36504 | N,N,N-tributyl-1-butanaminium (2R)-3-(3-chloro-4-methoxyphenyl)-2-([(E,5S,6S)-5-hydroxy-6-[(2R,3S)-3-phenyloxiranyl]-2-heptenoyl]amino)propanoate | C41H63ClN2O6 | 详情 | 详情 | |
| (V) | 58515 | N-(5-chloro-2-methoxyphenyl)-3,5-bis(trifluoromethyl)benzenecarbohydrazonamide | C16H12ClF6N3O | 详情 | 详情 |
Extended Information