　 -Drug Synthesis Database

【结构式】

【分子编号】58149

【品名】　

【CA登记号】

【分子式】C₆₈H₁₁₂O₃₅

【分子量】1489.61628

【元素组成】C 54.83% H 7.58% O 37.59%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(XVIII)

A new coupling of pentasaccharide (XVI) with thioglycoside (VII) produces heptasaccharide (XVII). Hydrolysis of the benzoate esters of (XVII), followed by O-methylation, yields methyl ether (XVIII).

参考文献中间体

合成目标

【1】 Petitou, M.; Herbert, J.-M.; Duchaussoy, P.; Basten, J.; Dreef-Tromp, C.; Driguez, P.-A.; Van Boeckel, C. (Akzo Nobel N.V.; Sanofi-Synthélabo); Synthetic polysaccharides, their method of production and pharmaceutical compsns. containing same. EP 1049721; FR 2773804; US 6528497; WO 9936443 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VII)	58138	(2R,4aR,6R,7R,8S,8aR)-7-(benzoyloxy)-6-{[(2R,3S,4S,5R,6S)-4,5-bis(benzoyloxy)-2-[(benzoyloxy)methyl]-6-(ethylsulfanyl)tetrahydro-2H-pyran-3-yl]oxy}-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-yl benzoate	C₅₆H₅₀O₁₅S	详情	详情
(XVI)	58147	((2R,3S,4S,5R,6R)-6-{[(2R,3S,4R,5R,6S)-6-{[(2R,3S,4R,5R,6R)-6-{[(2R,3S,4R,5R,6R)-6-{[(1R,2S,3R,4R,5R)-3,4-dimethoxy-6,8-dioxabicyclo[3.2.1]oct-2-yl]oxy}-4,5-dimethoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-4,5-dimethoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-4,5-dimethoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-3-hydroxy-4,5-dimethoxytetrahydro-2H-pyran-2-yl)methyl benzoate	C₅₀H₈₀O₂₆	详情	详情
(XVII)	58148		C₁₀₄H₁₂₄O₄₁	详情	详情
(XVIII)	58149		C₆₈H₁₁₂O₃₅	详情	详情

合成路线2

该中间体在本合成路线中的序号：(XVIII)

After acidic hydrolysis of the benzylidene acetal of (XVIII), esterification with 1-(benzoyloxy)-benzotriazole leads to (XIX). This is then coupled with a third moiety of disaccharide thioglycoside (VII), producing (XX).

参考文献中间体

合成目标

【1】 Petitou, M.; Herbert, J.-M.; Duchaussoy, P.; Basten, J.; Dreef-Tromp, C.; Driguez, P.-A.; Van Boeckel, C. (Akzo Nobel N.V.; Sanofi-Synthélabo); Synthetic polysaccharides, their method of production and pharmaceutical compsns. containing same. EP 1049721; FR 2773804; US 6528497; WO 9936443 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XVIII)	58149		C₆₈H₁₁₂O₃₅	详情	详情
(XIX)	58150		C₆₉H₁₁₄O₃₅	详情	详情
(XX)	58138	(2R,4aR,6R,7R,8S,8aR)-7-(benzoyloxy)-6-{[(2R,3S,4S,5R,6S)-4,5-bis(benzoyloxy)-2-[(benzoyloxy)methyl]-6-(ethylsulfanyl)tetrahydro-2H-pyran-3-yl]oxy}-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-yl benzoate	C₅₆H₅₀O₁₅S	详情	详情
(XXI)	58151		C₁₂₂H₁₅₆O₅₁	详情	详情

Extended Information