(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-2,3-dihydro-1H-inden-5-yl)-4-methyl-4-hexenoic acid -Drug Synthesis Database

【结构式】

【分子编号】58113

【品名】(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-2,3-dihydro-1H-inden-5-yl)-4-methyl-4-hexenoic acid

【CA登记号】

【分子式】C₁₈H₂₂O₅

【分子量】318.36968

【元素组成】C 67.91% H 6.97% O 25.13%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The esterification of mycophenolic acid (I) with 2-(4-morpholinyl)ethanol (II) in refluxing dibutyl ether or refluxing dipentyl ether with azeotropic distillation of water gives the target mycophenolic ester.

参考文献中间体

合成目标

【1】 Chudlik, M.; Husek, A. (Galena AS; Ivax Corp.); Method of mycophenolate mofetil preparation. WO 02100855 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	58113	(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-2,3-dihydro-1H-inden-5-yl)-4-methyl-4-hexenoic acid		C₁₈H₂₂O₅	详情	详情
(II)	12856	4-(2-Hydroxyethyl)morpholine; 2-(4-Morpholinyl)-1-ethanol; N-(2-Hydroxyethyl)morpholine	622-40-2	C₆H₁₃NO₂	详情	详情

Extended Information