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【结 构 式】 
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【分子编号】58105 【品名】(R)-2-Hydroxy-4-phenylbutyric acid ethyl ester; Ethyl (R)-2-hydroxy-4-phenylbutyrate 【CA登记号】90315-82-5 |
【 分 子 式 】C12H16O3 【 分 子 量 】208.25724 【元素组成】C 69.21% H 7.74% O 23.05% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of 2(R)-hydroxy-4-phenyl butyric acid ethyl ester (I) with trifluoromethanesulfonic anhydride in dichloromethane gives the corresponding triflate (II), which is then condensed with the amino benzazepinone (III) by means of NMM in the same solvent to provide the target benazepril.
| 【1】 Kumar, Y.; De, S.; Thaper, R.K.; Kumar, D.S.M. (Ranbaxy Laboratories Ltd.); Process for the preparation of benazepril. WO 0276375 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 58105 | (R)-2-Hydroxy-4-phenylbutyric acid ethyl ester; Ethyl (R)-2-hydroxy-4-phenylbutyrate | 90315-82-5 | C12H16O3 | 详情 | 详情 |
| (II) | 20818 | ethyl (2R)-4-phenyl-2-[[(trifluoromethyl)sulfonyl]oxy]butanoate | C13H15F3O5S | 详情 | 详情 | |
| (III) | 20895 | 2-[(3S)-3-amino-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid | C12H14N2O3 | 详情 | 详情 |
Extended Information