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【结 构 式】 
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【分子编号】58064 【品名】methyl 6-oxo-7-octenoate 【CA登记号】 |
【 分 子 式 】C9H14O3 【 分 子 量 】170.20836 【元素组成】C 63.51% H 8.29% O 28.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XLIV)The key dihydroxy ester intermediate (XIII) was also obtained by asymmetric hydrogenation of hydroxy ketoester (XLIII) in the presence of (S)-BINAP-dichlororuthenium catalyst. The precursor hydroxy ketoester (XLIII) was prepared by two alternative procedures. In one method, the racemic dihydroxy ester (XLII) was selectively oxidized to (XLIII) by means of NaOCl. In another method, the unsaturated keto ester (XLIV) was epoxidized by means of sodium percarbonate, and the resultant epoxide (XLV) was then reduced to the hydroxy ketoester (XLIII) by catalytic hydrogenation over PtO2.
| 【1】 Gewald, R. (Asta Medica AG); Method for producing enantiomer-free 6,8-dihydroxyoctanoic acid esters by means of asymmetric, catalytic hydrogenation. DE 10036516; WO 0210113 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIII) | 57977 | methyl (6S)-6,8-dihydroxyoctanoate | C9H18O4 | 详情 | 详情 | |
| (XLII) | 58066 | methyl 6,8-dihydroxyoctanoate | C9H18O4 | 详情 | 详情 | |
| (XLIII) | 58063 | methyl 8-hydroxy-6-oxooctanoate | C9H16O4 | 详情 | 详情 | |
| (XLIV) | 58064 | methyl 6-oxo-7-octenoate | C9H14O3 | 详情 | 详情 | |
| (XLV) | 58065 | methyl 6-(2-oxiranyl)-6-oxohexanoate | C9H14O4 | 详情 | 详情 |
Extended Information