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【结 构 式】

【分子编号】57933

【品名】2-benzoyl-5-methoxy-1H-indole-3-carboxylic acid

【CA登记号】

【 分 子 式 】C17H13NO4

【 分 子 量 】295.29456

【元素组成】C 69.15% H 4.44% N 4.74% O 21.67%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The alkaline hydrolysis of 5-methoxyisatin (I) provides the ortho-(aminophenyl)glyoxylic acid salt (II), which is then alkylated by 2-bromoacetophenone (III) to furnish the N-phenacylisatin (IV). Rearrangement of (IV) in the presence of NaOH gives rise to a 40:60 mixture of the indolecarboxylic acid (V) and the target decarboxylated compound.

1 Black, D.S.C.; Wong, L.C.H.; A simple synthesis of 2-acyl indoles from isatins. J Chem Soc Chem Commun 1980, 4, 200.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11892 5-Methoxy-1H-indole-2,3-dione 39755-95-8 C9H7NO3 详情 详情
(II) 57931 sodium 2-(2-amino-5-methoxyphenyl)-2-oxoacetate C9H8NNaO4 详情 详情
(III) 10315 2-Bromo-1-phenyl-ethanone; 2-Bromo-1-phenyl-1-ethanone 70-11-1 C8H7BrO 详情 详情
(IV) 57932 5-methoxy-1-(2-oxo-2-phenylethyl)-1H-indole-2,3-dione C17H13NO4 详情 详情
(V) 57933 2-benzoyl-5-methoxy-1H-indole-3-carboxylic acid C17H13NO4 详情 详情
Extended Information