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【结 构 式】

【分子编号】57930

【品名】[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl](phenyl)methanol

【CA登记号】

【 分 子 式 】C22H19NO4S

【 分 子 量 】393.4632

【元素组成】C 67.16% H 4.87% N 3.56% O 16.27% S 8.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

In a related method, the 2-lithio derivative of 5-methoxy-1-(phenylsulfonyl)indole (I) is condensed with benzaldehyde (II) to produce carbinol (III). Subsequent oxidation of (III) to the corresponding ketone (IV) is accomplished by treatment with pyridinium dichromate (PDC) in the presence of pyridinium trifluoroacetate (PTFA). Finally, the N-phenylsulfonyl group of (IV) is deprotected by treatment with tetrabutylammonium fluoride.

1 Teller, S.; Pongratz, H.; Mahboobi, S.; et al.; Bis(1H-2-indolyl) methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. J Med Chem 2002, 45, 5, 1002.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 57928 5-methoxy-1-(phenylsulfonyl)-1H-indole; methyl 1-(phenylsulfonyl)-1H-indol-5-yl ether C15H13NO3S 详情 详情
(II) 10498 Benzaldehyde;Benzoic aldehyde;Phenylmethanal 100-52-7 C7H6O 详情 详情
(III) 57930 [5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl](phenyl)methanol C22H19NO4S 详情 详情
(IV) 57929 [5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl](phenyl)methanone C22H17NO4S 详情 详情
Extended Information