【结 构 式】 |
【分子编号】57930 【品名】[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl](phenyl)methanol 【CA登记号】 |
【 分 子 式 】C22H19NO4S 【 分 子 量 】393.4632 【元素组成】C 67.16% H 4.87% N 3.56% O 16.27% S 8.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)In a related method, the 2-lithio derivative of 5-methoxy-1-(phenylsulfonyl)indole (I) is condensed with benzaldehyde (II) to produce carbinol (III). Subsequent oxidation of (III) to the corresponding ketone (IV) is accomplished by treatment with pyridinium dichromate (PDC) in the presence of pyridinium trifluoroacetate (PTFA). Finally, the N-phenylsulfonyl group of (IV) is deprotected by treatment with tetrabutylammonium fluoride.
【1】 Teller, S.; Pongratz, H.; Mahboobi, S.; et al.; Bis(1H-2-indolyl) methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. J Med Chem 2002, 45, 5, 1002. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 57928 | 5-methoxy-1-(phenylsulfonyl)-1H-indole; methyl 1-(phenylsulfonyl)-1H-indol-5-yl ether | C15H13NO3S | 详情 | 详情 | |
(II) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
(III) | 57930 | [5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl](phenyl)methanol | C22H19NO4S | 详情 | 详情 | |
(IV) | 57929 | [5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl](phenyl)methanone | C22H17NO4S | 详情 | 详情 |
Extended Information