N-benzyl-2-cyanoacetamide -Drug Synthesis Database

【结构式】

【分子编号】57914

【品名】N-benzyl-2-cyanoacetamide

【CA登记号】

【分子式】C₁₀H₁₀N₂O

【分子量】174.20228

【元素组成】C 68.95% H 5.79% N 16.08% O 9.18%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Reaction of methyl cyanoacetate (I) with benzylamine (II) at 100 C gives N-benzyl cyanoacetamide (III). Subsequent condensation of (III) with 3,4-dihydroxybenzaldehyde (IV) in the presence of NaH provides the title compound.

参考文献中间体

合成目标

【1】 Gazit, A.; et al.; Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem 1991, 34, 6, 1896.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	34458	Cyanoacetic acid methyl ester; methyl 2-cyanoacetate	105-34-0	C₄H₅NO₂	详情	详情
(II)	15147	Benzylamine; Phenylmethanamine	100-46-9	C₇H₉N	详情	详情
(III)	57914	N-benzyl-2-cyanoacetamide		C₁₀H₁₀N₂O	详情	详情
(IV)	39749	3,4-dihydroxybenzaldehyde	139-85-5	C₇H₆O₃	详情	详情

Extended Information