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【结 构 式】 
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【分子编号】57861 【品名】(+/-)-N-(2,6-Dioxo-3-piperidinyl)phthalimide; (+/-)-Thalidomide; (?-N-(2,6-Dioxo-3-piperidinyl)phthalimide; Thalidomide 【CA登记号】50-35-1 |
【 分 子 式 】C13H10N2O4 【 分 子 量 】258.23348 【元素组成】C 60.47% H 3.9% N 10.85% O 24.78% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of 2-(phthalimido)glutaric acid (I) with acetic anhydride and SOCl2 gives 2-(phthalimido)glutaric anhydride (II), which is treated with urea at 180 C to yield the target thalidomide. Alternatively, anhydride (II) can also be treated with ammonia in dioxane at 180 C in a pressure vessel.
| 【1】 (Grunenthal GmbH); Novel products of the amino-piperidine-2,6-dione series. GB 0768821 . |
| 【2】 Frankus, E.; Graudums, I.; Muckter, H. (Grunenthal GmbH); Derivs. of phthalimidines. GB 1185273 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 54082 | 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid | 2301-52-2 | C13H11NO6 | 详情 | 详情 |
| (II) | 57860 | N-Phthalyl-DL-glutamic anhydride; Phthalyl-Dl-Glutamic anhydride | 3085-92-5 | C13H9NO5 | 详情 | 详情 |
| (III) | 57861 | (+/-)-N-(2,6-Dioxo-3-piperidinyl)phthalimide; (+/-)-Thalidomide; (?-N-(2,6-Dioxo-3-piperidinyl)phthalimide; Thalidomide | 50-35-1 | C13H10N2O4 | 详情 | 详情 |
Extended Information