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【结 构 式】

【分子编号】57707

【品名】2-bromoethyl 1-naphthyl ether; 1-(2-bromoethoxy)naphthalene

【CA登记号】

【 分 子 式 】C12H11BrO

【 分 子 量 】251.12274

【元素组成】C 57.4% H 4.42% Br 31.82% O 6.37%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

Alkylation of 1-napthol (I) with 1,2-dibromoethane provides the (naphthyloxy)ethyl bromide (II), which is condensed with p-nitrophenethylamine (III) to afford the secondary amine (IV). After acetylation of amine (IV) to produce acetamide (V), the nitro group of (V) is reduced by means of iron and HCl, yielding aniline (VI). Finally, acylation of the amino group of (VI) with methanesulfonyl chloride furnishes the target sulfonamide.

1 Liu, H.; et al.; New p-methylsufonamido phenylamine analogues as class III antiarrhythmic agents: Design, synthesis, biological assay, and 3D-QSAR analysis. J Med Chem 2002, 45, 14, 2953.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22935 alpha-naphthol; 1-naphthol 90-15-3 C10H8O 详情 详情
(II) 57707 2-bromoethyl 1-naphthyl ether; 1-(2-bromoethoxy)naphthalene C12H11BrO 详情 详情
(III) 26560 4-nitrophenethylamine 24954-67-4 C8H10N2O2 详情 详情
(IV) 57708 2-(1-naphthyloxy)-N-(4-nitrophenethyl)-1-ethanamine; N-[2-(1-naphthyloxy)ethyl]-N-(4-nitrophenethyl)amine C20H20N2O3 详情 详情
(V) 57709 N-[2-(1-naphthyloxy)ethyl]-N-(4-nitrophenethyl)acetamide C22H22N2O4 详情 详情
(VI) 57710 N-(4-aminophenethyl)-N-[2-(1-naphthyloxy)ethyl]acetamide C22H24N2O2 详情 详情
Extended Information