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【结 构 式】 
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【分子编号】57692 【品名】4-(methoxymethyl)-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one 【CA登记号】 |
【 分 子 式 】C16H17NO3 【 分 子 量 】271.31592 【元素组成】C 70.83% H 6.32% N 5.16% O 17.69% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XII)Hydrolysis and cyclization of the dibromo acetate (XI) under basic conditions provides the furoquinoline (XII). Cleavage of the methyl ether group of (XII) using HBr in boiling HOAc gives bromide (XIII). Subsequent bromide displacement in (XIII) by sodium acetate yields acetate ester (XIV), which is finally hydrolyzed to the desired alcohol with methanolic KOH.
| 【1】 Chilin, A.; et al.; Synthesis and biological evaluation of a new furo(2,3-h)quinolin-2(1H)-one. J Med Chem 2002, 45, 5, 1146. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 57691 | 8-(2,3-dibromopropyl)-4-(methoxymethyl)-1,6-dimethyl-2-oxo-1,2-dihydro-7-quinolinyl acetate | C18H21Br2NO4 | 详情 | 详情 | |
| (XII) | 57692 | 4-(methoxymethyl)-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one | C16H17NO3 | 详情 | 详情 | |
| (XIII) | 57693 | 5-Hydroxyindole; 5-Indolol | 1953-54-4 | C8H7NO | 详情 | 详情 |
| (XIV) | 57694 | tert-butyl(dimethyl)silyl 1H-indol-5-yl ether; 5-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole | C14H21NOSi | 详情 | 详情 |
Extended Information