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【结 构 式】 
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【分子编号】57627 【品名】3-{6-amino-8-(3-fluorophenyl)-2-[2-(1-hydroxycyclohexyl)ethynyl]-9H-purin-9-yl}benzonitrile 【CA登记号】 |
【 分 子 式 】C26H21FN6O 【 分 子 量 】452.4909832 【元素组成】C 69.01% H 4.68% F 4.2% N 18.57% O 3.54% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)Displacement of the chloro group of (X) by means of ethanolic ammonia upon heating in a pressure vessel affords the amino purine (XI). The cyano group of (XI) is then hydrolyzed to the target amide with sodium peroxide, and the resultant compound is finally converted to the hydrochloride salt.
| 【1】 Asano, O.; Kawata, T.; Inoue, T.; Horizoe, T.; Yasuda, N.; Nagata, K.; Nagaoka, J.; Kobayashi, S.; Tanaka, I.; Abe, S.; Harada, H.; Murakami, M.; 2-Alkynyl-8-aryladenines possessing an amide moiety: Their synthesis and structure-activity relationships of effects on hepatic glucose production induced via agonism of the A2B adenosine receptor. Bioorg Med Chem 2001, 9, 10, 2709. |
| 【2】 Asano, O.; Hoshino, Y.; Kobayashi, S.; Nagata, K.; Harada, H.; Yoshikawa, S.; Nagaoka, J.; Inoue, T.; Horizoe, T.; Yasuda, N.; Murakami, M. (Eisai Co., Ltd.); Purine derivs. and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes. EP 1054012; JP 1999263789; WO 9935147 . |
Extended Information