【结 构 式】 |
【分子编号】57556 【品名】(2S,3R,4R,5S,6R)-6-{[((2R,3R,4R,5S,6R)-3-(acetylamino)-5-[(diphenoxyphosphoryl)oxy]-6-(methoxymethyl)-4-{[(3R)-3-(tetradecanoyloxy)tetradecyl]oxy}tetrahydro-2H-pyran-2-yl)oxy]methyl}-5-hydroxy-3-{[(3R)-3-hydroxytetradecanoyl]amino}-4-{[(3R)-3-hydroxytetradecyl]oxy}tetrahydro-2H-pyran-2-carboxylic acid 【CA登记号】 |
【 分 子 式 】C84H145N2O19P 【 分 子 量 】1518.051142 【元素组成】C 66.46% H 9.63% N 1.85% O 20.02% P 2.04% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XXXIII)Catalytic hydrogenolysis of the benzyl and benzhydryl groups of (XXXII) in the presence of Pearlman's catalyst provides (XXXIII). The phenyl phosphate ester groups of (XXXIII) are finally removed by hydrogenation over PtO2 to furnish the title compound.
【1】 Nishijima, M.; Kurakata, S.-I.; Shiozaki, M.; Mochizuki, T.; Kanai, S.; Watanabe, Y.; Synthesis of lipid A type pyran carboxylic acids with ether chains and their biological activities. Carbohydr Res 2001, 333, 3, 203. |
【2】 Shiozaki, M.; Kurakata, S.; Kanai, S.; Kazama, Y. (Sankyo Co., Ltd.); Ether type lipid A1-carboxylic acid analogues. EP 1152007; JP 2000297096; US 2002161221; US 6511965; WO 0047595 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XXXII) | 57555 | benzhydryl (2S,3R,4R,5S,6R)-6-{[((2R,3R,4R,5S,6R)-3-(acetylamino)-5-[(diphenoxyphosphoryl)oxy]-6-(methoxymethyl)-4-{[(3R)-3-(tetradecanoyloxy)tetradecyl]oxy}tetrahydro-2H-pyran-2-yl)oxy]methyl}-3-{[(3R)-3-(benzyloxy)tetradecanoyl]amino}-4-{[(3R)-3-(benzyloxy)tetradecyl]oxy}-5-hydroxytetrahydro-2H-pyran-2-carboxylate | C111H167N2O19P | 详情 | 详情 | |
(XXXIII) | 57556 | (2S,3R,4R,5S,6R)-6-{[((2R,3R,4R,5S,6R)-3-(acetylamino)-5-[(diphenoxyphosphoryl)oxy]-6-(methoxymethyl)-4-{[(3R)-3-(tetradecanoyloxy)tetradecyl]oxy}tetrahydro-2H-pyran-2-yl)oxy]methyl}-5-hydroxy-3-{[(3R)-3-hydroxytetradecanoyl]amino}-4-{[(3R)-3-hydroxytetradecyl]oxy}tetrahydro-2H-pyran-2-carboxylic acid | C84H145N2O19P | 详情 | 详情 |
Extended Information