6-(4-aminophenoxy)-3-pyridinamine; 6-(4-aminophenoxy)-3-pyridinylamine -Drug Synthesis Database

【结构式】

【分子编号】57426

【品名】6-(4-aminophenoxy)-3-pyridinamine; 6-(4-aminophenoxy)-3-pyridinylamine

【CA登记号】

【分子式】C₁₁H₁₁N₃O

【分子量】201.22796

【元素组成】C 65.66% H 5.51% N 20.88% O 7.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Coupling between 2-chloro-5-nitropyridine (I) and 4-nitrophenol (II) affords the diaryl ether (III). Subsequent catalytic hydrogenation of both nitro groups of (III) gives rise to diamine (IV). This is finally acylated with (S)-2,2-dimethylcyclopropanecarbonyl chloride (V) to furnish the title diamide.

参考文献中间体

合成目标

【1】 Yamamoto, T.; Iino, Y.; Kobayashi, T.; Fujita, K.; Hatanaka, T.; Kodaira, A.; Takehana, K.; Konishi, A. (Ajinomoto Co., Inc.); Heterocyclic cpds. and medicinal use thereof. EP 1193255; WO 0102359 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29610	2-chloro-5-nitropyridine	4548-45-2	C₅H₃ClN₂O₂	详情	详情
(II)	11236	4-Nitrophenol; p-Nitrophenol	100-02-7	C₆H₅NO₃	详情	详情
(III)	57425	4-nitrophenyl 5-nitro-2-pyridinyl ether; 5-nitro-2-(4-nitrophenoxy)pyridine		C₁₁H₇N₃O₅	详情	详情
(IV)	57426	6-(4-aminophenoxy)-3-pyridinamine; 6-(4-aminophenoxy)-3-pyridinylamine		C₁₁H₁₁N₃O	详情	详情
(V)	57427	(1S)-2,2-dimethylcyclopropanecarbonyl chloride		C₆H₉ClO	详情	详情

Extended Information