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【结 构 式】

【分子编号】57313

【品名】(1S,3S)-1-[(2R,3S,5R,6S)-3,6-dimethoxy-5-methyltetrahydro-2H-pyran-2-yl]-3-methyl-6-(trimethylsilyl)-5-hexynyl methyl ether; {(4S,6S)-6-[(2R,3S,5R,6S)-3,6-dimethoxy-5-methyltetrahydro-2H-pyran-2-yl]-6-methoxy-4-methyl-1-hexynyl}(trimethyl)silane

【CA登记号】

【 分 子 式 】C19H36O4Si

【 分 子 量 】356.57794

【元素组成】C 64% H 10.18% O 17.95% Si 7.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVII)

The selective protection of the primary OH group of hydroxymethyl tetrahydropyran-3-ol (X) with trityl chloride and pyridine gives the cyclohexanol (XI), which is methylated by means of methyl iodide and NaH to yield the dimethoxy derivative (XII). The cleavage of the trityl group of (XII) by means of HCl in methanol affords the methanol derivative (XIII), which is oxidized by means of DMP to the corresponding carbaldehyde (XIV). The condensation of (XIV) with 2(S)-methyl-5-(trimethylsilyl)-4-pentynyl iodide (XV) by means of t-BuLi and MgBr2 provides the acetylenic alcohol (XVI), which is methylated with methyl iodide and NaH giving the trimethoxy derivative (XVII). The hydrolysis of the acetal group of (XVII) with Ac-OH yields the hemiacetal (XVIII), which is olefinated with the phosphorane (XIX) in refluxing benzene to afford the unsaturated tridecanoic ester (XX). The reduction of (XX) with DIBAL provides the unsaturated diol (XXI), which is submitted to an asymmetric dihydroxylation by means of Ti(O-iPr)4, (+)-diethyl tartrate and tert-butyl hydroperoxide to give the chiral tetrahydropyran diol (XXII). The iodination of the triple bond of (XXII) with AlMe3, Cp2ZrCl2 and iodine yields the iodovinyl compound (XXIII), which is protected by means of Tbdms-Cl, DMAP and imidazole to afford the silylated compound (XXIV). The condensation of (XXIV) with the intermediate spiroenone (IX) by means of t-BuLi provides the open chain intermediate (XXV).

1 Gleason, J.L.; The total synthesis of FK-506 and its spiroketal analogs. Diss Abstr Int B - Sci Eng 1994, 54, 12, Part 1, 6206.
2 Ireland, R.E.; et al.; A total synthesis of FK-506. J Org Chem 1996, 61, 20, 6856.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IX) 57305 1-(tert-butyl) 2-((1S,2E)-3-((1R,3R,4R)-4-{[tert-butyl(diphenyl)silyl]oxy}-3-methoxycyclohexyl)-1-{(1R)-1-[(4R,6R)-2,2-dimethyl-9-oxo-1,3,7-trioxaspiro[5.5]undec-10-en-4-yl]ethyl}-2-methyl-2-propenyl) (2S)-1,2-piperidinedicarboxylate C50H71NO10Si 详情 详情
(X) 57306 (2R,3S,5R,6S)-2-(hydroxymethyl)-6-methoxy-5-methyltetrahydro-2H-pyran-3-ol C8H16O4 详情 详情
(XI) 57307 (2R,3S,5R,6S)-6-methoxy-5-methyl-2-[(trityloxy)methyl]tetrahydro-2H-pyran-3-ol C27H30O4 详情 详情
(XII) 57308 (2S,3R,5S,6R)-2,5-dimethoxy-3-methyl-6-[(trityloxy)methyl]tetrahydro-2H-pyran; [(2R,3S,5R,6S)-3,6-dimethoxy-5-methyltetrahydro-2H-pyran-2-yl]methyl trityl ether C28H32O4 详情 详情
(XIII) 57309 [(2R,3S,5R,6S)-3,6-dimethoxy-5-methyltetrahydro-2H-pyran-2-yl]methanol C9H18O4 详情 详情
(XIV) 57310 (2S,3S,5R,6S)-3,6-dimethoxy-5-methyltetrahydro-2H-pyran-2-carbaldehyde C9H16O4 详情 详情
(XV) 57311 [(4S)-5-iodo-4-methyl-1-pentynyl](trimethyl)silane C9H17ISi 详情 详情
(XVI) 57312 (1S,3S)-1-[(2R,3S,5R,6S)-3,6-dimethoxy-5-methyltetrahydro-2H-pyran-2-yl]-3-methyl-6-(trimethylsilyl)-5-hexyn-1-ol C18H34O4Si 详情 详情
(XVII) 57313 (1S,3S)-1-[(2R,3S,5R,6S)-3,6-dimethoxy-5-methyltetrahydro-2H-pyran-2-yl]-3-methyl-6-(trimethylsilyl)-5-hexynyl methyl ether; {(4S,6S)-6-[(2R,3S,5R,6S)-3,6-dimethoxy-5-methyltetrahydro-2H-pyran-2-yl]-6-methoxy-4-methyl-1-hexynyl}(trimethyl)silane C19H36O4Si 详情 详情
(XVIII) 57314 (3R,5S,6R)-5-methoxy-6-[(1S,3S)-1-methoxy-3-methyl-6-(trimethylsilyl)-5-hexynyl]-3-methyltetrahydro-2H-pyran-2-ol C18H34O4Si 详情 详情
(XIX) 14182 ethyl 2-(triphenyl-lambda(5)-phosphanylidene)acetate; (Carbethoxymethylene)triphenylphosphorane 1099-45-2 C22H21O2P 详情 详情
(XX) 57315 ethyl (E,4R,6S,7R,8S,10S)-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-13-(trimethylsilyl)-2-tridecen-12-ynoate C22H40O5Si 详情 详情
(XXI) 57316 (E,4R,6S,7R,8S,10S)-6,8-dimethoxy-4,10-dimethyl-13-(trimethylsilyl)-2-tridecen-12-yne-1,7-diol C20H38O4Si 详情 详情
(XXII) 57317 (1S)-1-{(2R,3R,5S,6R)-5-methoxy-6-[(1S,3S)-1-methoxy-3-methyl-6-(trimethylsilyl)-5-hexynyl]-3-methyltetrahydro-2H-pyran-2-yl}-1,2-ethanediol C20H38O5Si 详情 详情
(XXIII) 57318 (1S)-1-{(2R,3R,5S,6R)-6-[(1S,3S,5E)-6-iodo-1-methoxy-3,5-dimethyl-5-hexenyl]-5-methoxy-3-methyltetrahydro-2H-pyran-2-yl}-1,2-ethanediol C18H33IO5 详情 详情
(XXIV) 57319 (2R,3S,5R,6R)-6-((1S)-1,2-bis{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-[(1S,3S,5E)-6-iodo-1-methoxy-3,5-dimethyl-5-hexenyl]-5-methyltetrahydro-2H-pyran-3-yl methyl ether; (5S)-5-{(2R,3R,5S,6R)-6-[(1S,3S,5E)-6-iodo-1-methoxy-3,5-dimethyl-5-hexenyl]-5-methoxy-3-methyltetrahydro-2H-pyran-2-yl}-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane C30H61IO5Si2 详情 详情
(XXV) 57320 2-[(1S,2E)-1-[(1R)-1-((4S,6R,11R)-11-{(E,4S,6S)-6-[(2R,3S,5R,6R)-6-((1S)-1,2-bis{[tert-butyl(dimethyl)silyl]oxy}ethyl)-3-methoxy-5-methyltetrahydro-2H-pyran-2-yl]-6-methoxy-2,4-dimethyl-1-hexenyl}-2,2-dimethyl-9-oxo-1,3,7-trioxaspiro[5.5]undec-4-yl)ethyl]-3-((1R,3R,4R)-4-{[tert-butyl(diphenyl)silyl]oxy}-3-methoxycyclohexyl)-2-methyl-2-propenyl] 1-(tert-butyl) (2S)-1,2-piperidinedicarboxylate C80H133NO15Si3 详情 详情
Extended Information