(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 2-ethylphenylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】57216

【品名】(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 2-ethylphenylcarbamate

【CA登记号】

【分子式】C₂₂H₂₇N₃O₂

【分子量】365.4754

【元素组成】C 72.3% H 7.45% N 11.5% O 8.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The reaction of 2'-ethylphenserine (I) with MCPBA in chloroform gives the intermediate (II), which is treated in basic medium to yield the target geneserine derivative.

参考文献中间体

合成目标

【1】 Yu, Q.-S.; et al.; Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem 2002, 45, 17, 3684.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	57216	(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 2-ethylphenylcarbamate		C₂₂H₂₇N₃O₂	详情	详情
(II)	57217	(3aS,8aS)-5-{[(2-ethylanilino)carbonyl]oxy}-1,1,3a,8-tetramethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-1-ium		C₂₃H₃₀N₃O₂	详情	详情

Extended Information