7-methoxy-3-(methylsulfanyl)-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione -Drug Synthesis Database

【结构式】

【分子编号】57156

【品名】7-methoxy-3-(methylsulfanyl)-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione

【CA登记号】

【分子式】C₉H₁₀N₂O₃S₂

【分子量】258.32208

【元素组成】C 41.85% H 3.9% N 10.84% O 18.58% S 24.83%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The target thiadiazine dioxide has been obtained by reaction of 7-methoxy--3-(methylsulfanyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide (I) or 3-(1-imidazolyl)-7-methoxy-4H-1,2,4-benzothiadiazine-1,1-dioxide (II) with isopropylamine (III) at 120-150 C in a pressure vessel.

参考文献中间体

合成目标

【1】 Pirotte, B.; Lebrun, P.; De Tullio, P.; Somers, F.; Delarge, J.; Hansen, J.B.; Nielsen, F.E.; Hansen, H.C.; Mogensen, J.P.; Tagmose, T.M. (Novo Nordisk A/S); 1,2,4-Benzothiadiazine derivs. their preparation and use. EP 0906297; JP 2000512641; US 6242443; WO 9749692 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	57156	7-methoxy-3-(methylsulfanyl)-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione		C₉H₁₀N₂O₃S₂	详情	详情
(II)	23933	2-Propanamine; Isopropylamine	75-31-0	C₃H₉N	详情	详情
(III)	57157	3-(1H-imidazol-1-yl)-7-methoxy-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione		C₁₁H₁₀N₄O₃S	详情	详情

Extended Information