4-amino-4-phenylcyclohexanone -Drug Synthesis Database

【结构式】

【分子编号】57088

【品名】4-amino-4-phenylcyclohexanone

【CA登记号】

【分子式】C₁₂H₁₅NO

【分子量】189.25724

【元素组成】C 76.16% H 7.99% N 7.4% O 8.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XII)

Michael addition of methyl acrylate (VIII) to methyl phenylacetate (VII) in the presence of NaH produces the intermediate triester (IX) which, under the reaction conditions, undergoes Dieckmann cyclization to the cyclohexanone diester (X). Hydrolysis and decarboxylation of keto diester (X) leads to keto acid (XI). This is then subjected to Curtius rearrangement in the presence of diphenylphosphoryl azide (DPPA) to yield, after acidic hydrolysis of the intermediate isocyanate, the amino cyclohexanone (XII). Acylation of amine (XII) by acid chloride (VI) then gives amide (XIII).

参考文献中间体

合成目标

【1】 Elliott, J.M.; Castro Pineiro, J.L.; Swain, C.J.; Hollingworth, G.J.; Dinnell, K.; Shaw, D.E. (Merck Sharp & Dohme Ltd.); Cyclohexane derivs. and their use as therapeutic agents. WO 0187838 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VI)	57084	2-[3,5-bis(trifluoromethyl)phenyl]propanoyl chloride		C₁₁H₇ClF₆O	详情	详情
(VII)	32831	methyl 2-phenylacetate	101-41-7	C₉H₁₀O₂	详情	详情
(VIII)	14156	methyl acrylate	96-33-3	C₄H₆O₂	详情	详情
(IX)	57085	trimethyl 3-phenyl-1,3,5-pentanetricarboxylate		C₁₇H₂₂O₆	详情	详情
(X)	57086	dimethyl 4-oxo-1-phenyl-1,3-cyclohexanedicarboxylate		C₁₆H₁₈O₅	详情	详情
(XI)	57087	4-oxo-1-phenylcyclohexanecarboxylic acid		C₁₃H₁₄O₃	详情	详情
(XII)	57088	4-amino-4-phenylcyclohexanone		C₁₂H₁₅NO	详情	详情
(XIII)	57089	2-[3,5-bis(trifluoromethyl)phenyl]-N-(4-oxo-1-phenylcyclohexyl)propanamide		C₂₃H₂₁F₆NO₂	详情	详情

Extended Information