3-chloro-6-(1-piperazinyl)pyridazine -Drug Synthesis Database

【结构式】

【分子编号】57015

【品名】3-chloro-6-(1-piperazinyl)pyridazine

【CA登记号】

【分子式】C₈H₁₁ClN₄

【分子量】198.655

【元素组成】C 48.37% H 5.58% Cl 17.85% N 28.2%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 3,6-dichloropyridazine (I) with piperazine (II) by means of TEA in refluxing toluene gives 3-chloro-6-(1-piperazinyl)pyridazine (III), which is methylated with HCHO/ HCOOH at 110 C, yielding 3-chloro-6-(4-methylpiperazin-1-yl)pyridazine (IV). Finally, this compound is quaternized with methyl iodide in ethyl ether to provide the target dimethylpiperidinium salt.

参考文献中间体

合成目标

【1】 Toma, L.; et al.; 6-Chloropyridazin-3-yl derivatives active as nicotinic agents: Synthesis, binding, and modeling studies. J Med Chem 2002, 45, 18, 4011.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11292	3,6-Dichloropyridazine	141-30-0	C₄H₂Cl₂N₂	详情	详情
(II)	10355	Diethylenediamine; Piperazine	110-85-0	C₄H₁₀N₂	详情	详情
(III)	57015	3-chloro-6-(1-piperazinyl)pyridazine		C₈H₁₁ClN₄	详情	详情
(IV)	53381	3-chloro-6-(4-methyl-1-piperazinyl)pyridazine	27464-17-1	C₉H₁₃ClN₄	详情	详情

Extended Information