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【结 构 式】

【分子编号】56990

【品名】dimethyl 3-[3-(methoxymethyl)phenyl]-2-oxopropylphosphonate

【CA登记号】

【 分 子 式 】C13H19O5P

【 分 子 量 】286.264622

【元素组成】C 54.54% H 6.69% O 27.95% P 10.82%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(III)

In an alternative method, oxidation of the lactone alcohol (I) using DMSO in the presence of SO3-pyridine complex gives aldehyde (II). Horner-Emmons condensation of aldehyde (II) with phosphonate (III) affords enone (IV). Stereoselective reduction of (IV) with LiAlH4 in the presence of (S)-BINOL provides the (S)-alcohol (V), which is further protected with dihydropyran in the presence of p-toluenesulfonic acid to yield the bis-tetrahydropyranyl ether (VI). Lactone ring opening in (VI) under reductive conditions leads to diol (VII). Selective mesylation of the primary alcohol of (VII), followed by protection of the secondary hydroxyl with chlorotrimethylsilane produces the intermediate mesylate (VIII), which is then displaced with potassium thioacetate to yield the thioacetate ester (IX).

1 Maruyama, T.; et al.; Design and synthesis of a selective EP4-receptor agonist. Part 4: Practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist. Bioorg Med Chem 2002, 10, 7, 2103.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 56988 (3aR,4S,5R,6aS)-4-(hydroxymethyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one C13H20O5 详情 详情
(II) 56989 (3aR,4R,5R,6aS)-2-oxo-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-4-carbaldehyde C13H18O5 详情 详情
(III) 56990 dimethyl 3-[3-(methoxymethyl)phenyl]-2-oxopropylphosphonate C13H19O5P 详情 详情
(IV) 56991 (3aR,4R,5R,6aS)-4-{(E)-4-[3-(methoxymethyl)phenyl]-3-oxo-1-butenyl}-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one C24H30O6 详情 详情
(V) 56992 (3aR,4R,5R,6aS)-4-{(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl}-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one C24H32O6 详情 详情
(VI) 56993 (3aR,4R,5R,6aS)-4-[(E,3S)-4-[3-(methoxymethyl)phenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one C29H40O7 详情 详情
(VII) 56994 (1S,2R,3R,4R)-2-(2-hydroxyethyl)-3-[(E,3S)-4-[3-(methoxymethyl)phenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-4-(tetrahydro-2H-pyran-2-yloxy)cyclopentanol C29H44O7 详情 详情
(VIII) 56995 2-{(1R,2R,3R,5S)-2-[(E,3S)-4-[3-(methoxymethyl)phenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-5-[(trimethylsilyl)oxy]cyclopentyl}ethyl methanesulfonate C33H54O9SSi 详情 详情
(IX) 56996 S-(2-{(1R,2R,3R,5S)-2-[(E,3S)-4-[3-(methoxymethyl)phenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-5-[(trimethylsilyl)oxy]cyclopentyl}ethyl) ethanethioate C34H54O7SSi 详情 详情

合成路线2

该中间体在本合成路线中的序号:(III)

Oxidation of the lactone alcohol (I) using DMSO in the presence of SO3-pyridine complex gives aldehyde (II). Horner-Emmons condensation of aldehyde (II) with phosphonate (III) affords enone (IV). Stereoselective reduction of (IV) with LiAlH4 in the presence of (S)-BINOL provides the (S)-alcohol (V), which is further protected with dihydropyran in the presence of p-toluenesulfonic acid to yield the bis-tetrahydropyranyl ether (VI). Lactone ring opening in (VI) under reductive conditions leads to diol (VII). Selective mesylation of the primary alcohol of (VII), followed by protection of the secondary hydroxyl with chlorotrimethylsilane produces the intermediate mesylate (VIII), which is then displaced with potassium thioacetate to yield the thioacetate ester (IX).

1 Maruyama, T.; et al.; Design and synthesis of a selective EP4-receptor agonist. Part 4: Practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist. Bioorg Med Chem 2002, 10, 7, 2103.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 56988 (3aR,4S,5R,6aS)-4-(hydroxymethyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one C13H20O5 详情 详情
(II) 56989 (3aR,4R,5R,6aS)-2-oxo-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-4-carbaldehyde C13H18O5 详情 详情
(III) 56990 dimethyl 3-[3-(methoxymethyl)phenyl]-2-oxopropylphosphonate C13H19O5P 详情 详情
(IV) 56991 (3aR,4R,5R,6aS)-4-{(E)-4-[3-(methoxymethyl)phenyl]-3-oxo-1-butenyl}-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one C24H30O6 详情 详情
(V) 56992 (3aR,4R,5R,6aS)-4-{(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl}-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one C24H32O6 详情 详情
(VI) 56993 (3aR,4R,5R,6aS)-4-[(E,3S)-4-[3-(methoxymethyl)phenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one C29H40O7 详情 详情
(VII) 56994 (1S,2R,3R,4R)-2-(2-hydroxyethyl)-3-[(E,3S)-4-[3-(methoxymethyl)phenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-4-(tetrahydro-2H-pyran-2-yloxy)cyclopentanol C29H44O7 详情 详情
(VIII) 56995 2-{(1R,2R,3R,5S)-2-[(E,3S)-4-[3-(methoxymethyl)phenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-5-[(trimethylsilyl)oxy]cyclopentyl}ethyl methanesulfonate C33H54O9SSi 详情 详情
(IX) 56996 S-(2-{(1R,2R,3R,5S)-2-[(E,3S)-4-[3-(methoxymethyl)phenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-1-butenyl]-3-(tetrahydro-2H-pyran-2-yloxy)-5-[(trimethylsilyl)oxy]cyclopentyl}ethyl) ethanethioate C34H54O7SSi 详情 详情
Extended Information