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【结 构 式】 
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【分子编号】56892 【品名】(1R,2S)-6,7-dimethoxy-2-methyl-2-[3-(sulfonatooxy)propyl]-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium 【CA登记号】 |
【 分 子 式 】C25H35NO9S 【 分 子 量 】525.62024 【元素组成】C 57.13% H 6.71% N 2.66% O 27.4% S 6.1% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of (R)-(-)-5'-methoxylaudanosine (I) with 1,3-dioxa-2-thiane 2,2-dioxide (II) in hot acetone gives the quaternized propylsulfonate (III), which is treated with Ac-Cl in methanol to yield the intermediate isoquinolinium derivative (IV).
| 【1】 Samano, V.; et al.; Synthesis of ultra-short-acting neuromuscular blocker GW 0430: A remarkably stereo- and regioselective synthesis of mixed tetrahydroisquinolinium chlorofumarates. Org Lett 1999, 1, 12, 1993. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19489 | (1R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline; 4-[[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl]-2,6-dimethoxyphenyl methyl ether | C22H29NO5 | 详情 | 详情 | |
| (II) | 56891 | 1,3-propanediol cyclic sulfate;1,3,2-dioxathiane 2,2-dioxide;1,3-Propylene sulfate | 1073-05-8 | C3H6O4S | 详情 | 详情 |
| (III) | 56892 | (1R,2S)-6,7-dimethoxy-2-methyl-2-[3-(sulfonatooxy)propyl]-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium | C25H35NO9S | 详情 | 详情 | |
| (IV) | 56893 | (1R,2S)-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium chloride | C25H36ClNO6 | 详情 | 详情 |
Extended Information