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【结 构 式】 
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【分子编号】56836 【品名】(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentanedioic acid 【CA登记号】 |
【 分 子 式 】C20H23N7O7 【 分 子 量 】473.4456 【元素组成】C 50.74% H 4.9% N 20.71% O 23.66% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXVIa)In a further method for the separation of the diastereomeric mixture, (6R,S)-folinic acid (XXVIa-b) was converted to the alpha 2,6-dichlorobenzyl ester upon treatment with 2,6-dichlorobenzyl bromide (XXVII) and Na2CO3. The resultant diastereomeric esters were easily separated by column chromatography to provide the (6S)-isomer (XXVIII), which was finally converted to the title compound by saponification of the benzyl ester group.
| 【1】 Fitzhugh, A.L.; Akee, R.K. (US Department of Health & Human Services); Process for separating the diastereomers of (6R,6S)-5,6,7,8-tetrahydrofolic acid derivs.. US 5698693 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXVIa) | 56836 | (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentanedioic acid | C20H23N7O7 | 详情 | 详情 | |
| (XXVIb) | 56837 | (2S)-2-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentanedioic acid | C20H23N7O7 | 详情 | 详情 | |
| (XXVII) | 40793 | 2-(bromomethyl)-1,3-dichlorobenzene | 20443-98-5 | C7H5BrCl2 | 详情 | 详情 |
| (XXVIII) | 56838 | (4S)-4-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}-5-[(2,6-dichlorobenzyl)oxy]-5-oxopentanoic acid | C27H27Cl2N7O7 | 详情 | 详情 |
Extended Information