ethyl 5-({[(E)-[3-(hydroxymethyl)phenyl](3-pyridinyl)methylidene]amino}oxy)pentanoate -Drug Synthesis Database

【结构式】

【分子编号】56591

【品名】ethyl 5-({[(E)-[3-(hydroxymethyl)phenyl](3-pyridinyl)methylidene]amino}oxy)pentanoate

【CA登记号】

【分子式】C₂₀H₂₄N₂O₄

【分子量】356.42164

【元素组成】C 67.4% H 6.79% N 7.86% O 17.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

Ketone (I) was converted to the corresponding oxime (II) by treatment with hydroxylamine hydrochloride and pyridine. Subsequent alkylation of the oxime (II) with ethyl 5-bromovalerate (III) in the presence of NaH provided (IV). After desilylation of (IV) by means of tetrabutylammonium fluoride, the liberated alcohol (V) was converted to mesylate (VI). The title compound was then obtained by condensation of mesylate (VI) with the pyridothienotriazolodiazepine derivative (VII).

参考文献中间体

合成目标

【1】 Sano, T.; Seki, T.; Fujita, M.; Inada, H. (Nikken Chemicals Co., Ltd.); Triazolo-1,4-diazepine cpds. and medicinal compsn. containing the same. EP 0995752; JP 1999071378; US 6433167; WO 9858930 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	56588	[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)phenyl](3-pyridinyl)methanone		C₂₉H₂₉NO₂Si	详情	详情
(II)	56589	[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)phenyl](3-pyridinyl)methanone oxime		C₂₉H₃₀N₂O₂Si	详情	详情
(III)	37151	ethyl 5-bromopentanoate	14660-52-7	C₇H₁₃BrO₂	详情	详情
(IV)	56590	ethyl 5-({[(E)-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)phenyl](3-pyridinyl)methylidene]amino}oxy)pentanoate		C₃₆H₄₂N₂O₄Si	详情	详情
(V)	56591	ethyl 5-({[(E)-[3-(hydroxymethyl)phenyl](3-pyridinyl)methylidene]amino}oxy)pentanoate		C₂₀H₂₄N₂O₄	详情	详情
(VI)	56592	ethyl 5-({[(E)-(3-{[(methylsulfonyl)oxy]methyl}phenyl)(3-pyridinyl)methylidene]amino}oxy)pentanoate		C₂₁H₂₆N₂O₆S	详情	详情
(VII)	14057	6-(2-Chlorophenyl)-1,4-dimethyl-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine		C₁₉H₁₈ClN₅S	详情	详情

Extended Information