【结 构 式】 |
【分子编号】56542 【品名】2,2,2-trichloroethyl 2-bromoacetate 【CA登记号】 |
【 分 子 式 】C4H4BrCl3O2 【 分 子 量 】270.33666 【元素组成】C 17.77% H 1.49% Br 29.56% Cl 39.34% O 11.84% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XII)Alternatively, alkylation of diclofenac sodium (I) with either trichloroethyl bromoacetate (XII) of tribromoethyl bromoacetate (XIII) gave rise to the respective trichloroethyl (XIV) and tribromoethyl (XV) esters of aceclofenac. Reductive cleavage of the trihaloethyl esters (XIV) and (XV) using zinc powder under acidic conditions furnished the title compound.
【1】 Frank, A.; Karn, H.; Spanig, H. (Abbott GmbH & Co. KG); Production of 1-hydroxyalkyl-5-nitroimidazoles. DE 2359625; FR 2253019; GB 1481349 . |
【2】 Frank, A.; Dockner, T.; Karn, H. (Abbott GmbH & Co. KG); Process for the preparation of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole of high purity. EP 0150407 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 56535 | sodium 2-[2-(2,6-dichloroanilino)phenyl]acetate | C14H10Cl2NNaO2 | 详情 | 详情 | |
(XII) | 56542 | 2,2,2-trichloroethyl 2-bromoacetate | C4H4BrCl3O2 | 详情 | 详情 | |
(XIII) | 56543 | 2,2,2-tribromoethyl 2-bromoacetate | C4H4Br4O2 | 详情 | 详情 | |
(XIV) | 56544 | 2-oxo-2-(2,2,2-trichloroethoxy)ethyl 2-[2-(2,6-dichloroanilino)phenyl]acetate | C18H14Cl5NO4 | 详情 | 详情 | |
(XV) | 56545 | 2-oxo-2-(2,2,2-tribromoethoxy)ethyl 2-[2-(2,6-dichloroanilino)phenyl]acetate | C18H14Br3Cl2NO4 | 详情 | 详情 |
Extended Information