2-oxo-2-(tetrahydro-2H-pyran-2-yloxy)ethyl 2-[2-(2,6-dichloroanilino)phenyl]acetate -Drug Synthesis Database

【结构式】

【分子编号】56540

【品名】2-oxo-2-(tetrahydro-2H-pyran-2-yloxy)ethyl 2-[2-(2,6-dichloroanilino)phenyl]acetate

【CA登记号】

【分子式】C₂₁H₂₁Cl₂NO₅

【分子量】438.30688

【元素组成】C 57.55% H 4.83% Cl 16.18% N 3.2% O 18.25%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

Aceclofenac was prepared by selective hydrolysis of other labile ester precursors. Alkylation of diclofenac sodium (I) with tetrahydropyranyl chloroacetate (IX), prepared by protection of chloroacetic acid (VIII) with dihydropyran, furnished the tetrahydropyranyl ester of aceclofenac (X), which was then deprotected by treatment with HCl. Similarly, the preparation of aceclofenac was reported by acidic hydrolysis of the analogous tetrahydrofuranyl ester (XI).

参考文献中间体

合成目标

【1】 Flores Ramos, R. (Almirall Prodesfarma, SA); Process for obtaining 2-[(2,6-dichlorophenyl)amino]phenylacetoxy acetic acid. ES 2046141 .
【2】 Zirngibl, L.; Gnehm, R. (Siegfried AG); Process for the preparation of a phenylacetic acid deriv.. CH 682747 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	56535	sodium 2-[2-(2,6-dichloroanilino)phenyl]acetate		C₁₄H₁₀Cl₂NNaO₂	详情	详情
(VIII)	11847	2-Chloroacetic acid; Chloroacetic Acid	79-11-8	C₂H₃ClO₂	详情	详情
(IX)	56539	tetrahydro-2H-pyran-2-yl 2-chloroacetate		C₇H₁₁ClO₃	详情	详情
(X)	56540	2-oxo-2-(tetrahydro-2H-pyran-2-yloxy)ethyl 2-[2-(2,6-dichloroanilino)phenyl]acetate		C₂₁H₂₁Cl₂NO₅	详情	详情
(XI)	56541	2-oxo-2-(tetrahydro-2-furanyloxy)ethyl 2-[2-(2,6-dichloroanilino)phenyl]acetate		C₂₀H₁₉Cl₂NO₅	详情	详情

Extended Information