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【结 构 式】 
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【分子编号】56375 【品名】 【CA登记号】 |
【 分 子 式 】C14H24O6 【 分 子 量 】288.34096 【元素组成】C 58.32% H 8.39% O 33.29% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Monomethyl suberate (I) is treated with isobutyl chloroformate to produce the mixed anhydride (II), which is subsequently coupled with 3-aminopyridine (III), yielding amide (IV). The methyl ester group of (IV) is finally converted to the target hydroxamate upon treatment with methanolic hydroxylamine.
| 【1】 Gilbert, J.; et al.; A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies. Clin Cancer Res 2001, 7, 8, 2292. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56374 | Methyl hydrogen octane-1,8-dioate; Monomethyl suberate; Octanedioic acid monomethyl ester; Suberic acid monomethyl ester | 3946-32-5 | C9H16O4 | 详情 | 详情 |
| (II) | 56375 | C14H24O6 | 详情 | 详情 | ||
| (III) | 33327 | 3-Pyridinylamine; 3-Aminopyridine; 3-Pyridinamine | 462-08-8 | C5H6N2 | 详情 | 详情 |
| (IV) | 56376 | methyl 8-oxo-8-(3-pyridinylamino)octanoate | C14H20N2O3 | 详情 | 详情 |
Extended Information