ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】56322

【品名】ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate

【CA登记号】

【分子式】C₂₆H₃₀N₆O₃

【分子量】474.56284

【元素组成】C 65.8% H 6.37% N 17.71% O 10.11%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XI)

In a further patented method, the biphenylyl nitrile (X) was converted to tetrazole (XI) by dipolar cycloaddition with sodium azide in the presence of triethylammonium chloride. Subsequent basic hydrolysis of the ethyl ester function of (XI) yielded the corresponding carboxylic acid.

参考文献中间体

合成目标

【1】 Koguro, K.; Oga, T.; Tokunaga, N.; Mitsui, S.; Orita, R. (Tokyo Kasei Kogyo Co., Ltd.); Process for preparation of 5-substd. tetrazoles. EP 0796852 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(X)	16909	ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate		C₄₅H₄₄N₆O₃	详情	详情
(XI)	56322	ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate		C₂₆H₃₀N₆O₃	详情	详情

Extended Information