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【结 构 式】 
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【分子编号】56321 【品名】methyl N-[(Z)-2-amino-1,2-dicyanoethenyl]butanimidoate 【CA登记号】 |
【 分 子 式 】C9H12N4O 【 分 子 量 】192.22064 【元素组成】C 56.24% H 6.29% N 29.15% O 8.32% |
合成路线1
该中间体在本合成路线中的序号：(III)Condensation of diaminomaleonitrile (I) with trimethyl orthobutyrate (II) produced the imino ether (III), which was further cyclized to imidazole (IV) upon heating in xylene. Acid hydrolysis of the imidazole dinitrile (IV) led to diacid (V), and subsequent Fischer esterification with ethanolic HCl provided diester (VI). Regioselective addition of methylmagnesium bromide to diester (VI) furnished the imidazole carbinol (VII). Alkylation of imidazole (VII) with the biphenyl bromide (VIII) furnished the (biphenylylmethyl)imidazole (IX). Then, removal of the trityl protecting group of (IX) under acidic conditions, followed by alkaline ester hydrolysis gave rise to the title compound.
| 【1】 Yanagisawa, H.; Shimoji, Y.; Fujimoto, K.; Kanazaki, T.; Anemiya, Y.; Koike, H.; Sada, T. (Sankyo Co., Ltd.); Angiotensin II antagonist 1-biphenylmethylimidazole cpds. and their therapeutic use. EP 0503785; EP 0545912; JP 1993078328; US 5616599 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16903 | (Z)-2,3-diamino-2-butenedinitrile;diaminomaleonitrile | 1187-42-4 | C4H4N4 | 详情 | 详情 |
| (II) | 16902 | 1,1-dimethoxybutyl methyl ether; 1,1,1-trimethoxybutane | 43083-12-1 | C7H16O3 | 详情 | 详情 |
| (III) | 56321 | methyl N-[(Z)-2-amino-1,2-dicyanoethenyl]butanimidoate | C9H12N4O | 详情 | 详情 | |
| (IV) | 16904 | 2-propyl-1H-imidazole-4,5-dicarbonitrile | C8H8N4 | 详情 | 详情 | |
| (V) | 16905 | 2-propyl-1H-imidazole-4,5-dicarboxylic acid | C8H10N2O4 | 详情 | 详情 | |
| (VI) | 16906 | diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate | C12H18N2O4 | 详情 | 详情 | |
| (VII) | 16907 | ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate | C12H20N2O3 | 详情 | 详情 | |
| (VIII) | 15538 | 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-trityl-2H-1,2,3,4-tetraazole | 124750-51-2 | C33H25BrN4 | 详情 | 详情 |
| (IX) | 16909 | ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate | C45H44N6O3 | 详情 | 详情 |