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【结 构 式】 
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【分子编号】56162 【品名】4-chlorobutyl 2-(6-methoxy-2-naphthyl)propanoate 【CA登记号】 |
【 分 子 式 】C18H21ClO3 【 分 子 量 】320.81564 【元素组成】C 67.39% H 6.6% Cl 11.05% O 14.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The sodium salt (II), prepared from racemic naproxen (I), was alkylated with 1-bromo-4-chlorobutane (III) in DMF to produce the 4-chlorobutyl ester (IV). Chloride displacement in (IV) by silver nitrate in hot acetonitrile gave rise to the target nitrate ester.
| 【1】 Del Soldato, P.; Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation. WO 9509831 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 42596 | 2-(6-methoxy-2-naphthyl)propionic acid | 23981-80-8 | C14H14O3 | 详情 | 详情 |
| (II) | 56161 | sodium 2-(6-methoxy-2-naphthyl)propanoate | C14H13NaO3 | 详情 | 详情 | |
| (III) | 16141 | 1-bromo-4-chlorobutane | 6940-78-9 | C4H8BrCl | 详情 | 详情 |
| (IV) | 56162 | 4-chlorobutyl 2-(6-methoxy-2-naphthyl)propanoate | C18H21ClO3 | 详情 | 详情 |
Extended Information