1-(3-methoxyphenyl)ethylformamide -Drug Synthesis Database

【结构式】

【分子编号】56139

【品名】1-(3-methoxyphenyl)ethylformamide

【CA登记号】

【分子式】C₁₀H₁₃NO₂

【分子量】179.21876

【元素组成】C 67.02% H 7.31% N 7.82% O 17.85%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The required (R)-3-methoxy-alpha-methylbenzylamine (III) was prepared from 3’-methoxyacetophenone (I) via Leuckart reaction, upon heating at 180 C with ammonium formate. The resultant formamide (II) was hydrolyzed with concentrated HCl to the racemic amine, which was then resolved using (R)-mandelic acid.

参考文献中间体

合成目标

【1】 D'Ambra, T.E.; Vanwagenen, B.C.; Duff, S.R.; Nelson, W.A. (NPS Pharmaceuticals, Inc.); Method of making a benzylpropanamine. WO 9602492 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18792	3-methoxyacetophenone; 1-(3-methoxyphenyl)-1-ethanone	586-37-8	C₉H₁₀O₂	详情	详情
(II)	56139	1-(3-methoxyphenyl)ethylformamide		C₁₀H₁₃NO₂	详情	详情
(III)	56140	(R)-1-(3-Methoxyphenyl)ethylamine; (R)-3-Methoxy-alpha-methylbenzylamine; (R)-m-Methoxy-alpha-methylbenzylamine	88196-70-7	C₉H₁₃NO	详情	详情

Extended Information