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【结 构 式】 
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【分子编号】56109 【品名】2-Meethylindole-3-carboxaldehyde 【CA登记号】 |
【 分 子 式 】C10H9NO 【 分 子 量 】159.1876 【元素组成】C 75.45% H 5.7% N 8.8% O 10.05% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)2-Methyl-3-(methylaminomethyl)indole (II) was obtained by the reductive amination of indole aldehyde (I) with methylamine. Acylation of amine (II) with acryloyl chloride (III) furnished the corresponding acrylamide (IV).
| 【1】 Uzinskas, I.N.; Miller, W.H.; Newlander, K.A.; Jakas, D.R.; Seefeld, M.A.; DeWolf, W.E. Jr. (GlaxoSmithKline Inc.); Fab I inhibitors. EP 1226138; WO 0127103 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56109 | 2-Meethylindole-3-carboxaldehyde | C10H9NO | 详情 | 详情 | |
| (II) | 56110 | N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]amine; N-methyl(2-methyl-1H-indol-3-yl)methanamine | C11H14N2 | 详情 | 详情 | |
| (III) | 11577 | Acryloyl chloride; Acrylyl chloride;2-Propenoyl chloride | 814-68-6 | C3H3ClO | 详情 | 详情 |
| (IV) | 56111 | N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]acrylamide | C14H16N2O | 详情 | 详情 |
Extended Information