bis(trimethylsilyl) (2S)-2-aminopentanedioate -Drug Synthesis Database

【结构式】

【分子编号】55620

【品名】bis(trimethylsilyl) (2S)-2-aminopentanedioate

【CA登记号】

【分子式】C₁₁H₂₅NO₄Si₂

【分子量】291.49484

【元素组成】C 45.33% H 8.64% N 4.81% O 21.95% Si 19.27%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

In a related method for the preparation of (IV), acid (I) was activated as the mixed anhydride (V) using isobutyl chloroformate. Coupling of anhydride (V) with the silyl ester (VI), prepared from glutamic acid (III) and hexamethyldisilazane, provided amide (IV).

参考文献中间体

合成目标

【1】 Biseniex, E.A.; Uldrikis, Y.R.; Dubur, G.Y.; Veveris, M.M.; Kimenis, A.A.; Ivanov, E.V. (Latvian Institute of Organic Synthesis); 2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide) glutaric acid its disodium salt and method of their preparation. US 4485239 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	55616	3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinecarboxylic acid		C₁₄H₁₉NO₆	详情	详情
(III)	12005	L-2-Amino propane dicarboxylic acid; (-)-2-Aminoglutaric acid; L-2-Aminopentanoic acid; L-Glutamic acid	56-86-0	C₅H₉NO₄	详情	详情
(IV)	55618	(2S)-2-({[3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinyl]carbonyl}amino)pentanedioic acid		C₁₉H₂₆N₂O₉	详情	详情
(V)	55619			C₁₉H₂₇NO₈	详情	详情
(VI)	55620	bis(trimethylsilyl) (2S)-2-aminopentanedioate		C₁₁H₂₅NO₄Si₂	详情	详情

Extended Information