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【结 构 式】

【分子编号】55620

【品名】bis(trimethylsilyl) (2S)-2-aminopentanedioate

【CA登记号】

【 分 子 式 】C11H25NO4Si2

【 分 子 量 】291.49484

【元素组成】C 45.33% H 8.64% N 4.81% O 21.95% Si 19.27%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

In a related method for the preparation of (IV), acid (I) was activated as the mixed anhydride (V) using isobutyl chloroformate. Coupling of anhydride (V) with the silyl ester (VI), prepared from glutamic acid (III) and hexamethyldisilazane, provided amide (IV).

1 Biseniex, E.A.; Uldrikis, Y.R.; Dubur, G.Y.; Veveris, M.M.; Kimenis, A.A.; Ivanov, E.V. (Latvian Institute of Organic Synthesis); 2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide) glutaric acid its disodium salt and method of their preparation. US 4485239 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 55616 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinecarboxylic acid C14H19NO6 详情 详情
(III) 12005 L-2-Amino propane dicarboxylic acid; (-)-2-Aminoglutaric acid; L-2-Aminopentanoic acid; L-Glutamic acid 56-86-0 C5H9NO4 详情 详情
(IV) 55618 (2S)-2-({[3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinyl]carbonyl}amino)pentanedioic acid C19H26N2O9 详情 详情
(V) 55619   C19H27NO8 详情 详情
(VI) 55620 bis(trimethylsilyl) (2S)-2-aminopentanedioate C11H25NO4Si2 详情 详情
Extended Information