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【结 构 式】 
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【分子编号】55613 【品名】(4R)-3-[2-(2,3-dihydro-1H-inden-2-yl)acetyl]-1,3-thiazolidine-4-carboxylic acid 【CA登记号】 |
【 分 子 式 】C15H17NO3S 【 分 子 量 】291.37092 【元素组成】C 61.83% H 5.88% N 4.81% O 16.47% S 11.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)Coupling of indanylacetic acid (IV) with L-thioproline ethyl ester (V) by means of EDC gave amide (VI). Subsequent saponification of the ethyl ester group of (VI) furnished (indanylacetyl)thioproline (VII). The title compound was finally obtained by coupling of acid (VII) with pyrrolidine (VIII).
| 【1】 Aotsuka, T.; Torizuka, M.; Soeda, M.; Ogura, K.; Tanaka, Y.; Kato, H.; Nakata, N.; Miura, N.; Morita, H. (Zeria Pharmaceutical Co., Ltd.); Condensed benzene deriv.. AU 8945914; EP 0372484; JP 1990262557; US 5028604 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 21721 | 2-(2,3-dihydro-1H-inden-2-yl)acetic acid | 37868-26-1 | C11H12O2 | 详情 | 详情 |
| (V) | 12901 | ethyl (4R)-1,3-thiazolidine-4-carboxylate | C6H11NO2S | 详情 | 详情 | |
| (VI) | 55612 | ethyl (4R)-3-[2-(2,3-dihydro-1H-inden-2-yl)acetyl]-1,3-thiazolidine-4-carboxylate | C17H21NO3S | 详情 | 详情 | |
| (VII) | 55613 | (4R)-3-[2-(2,3-dihydro-1H-inden-2-yl)acetyl]-1,3-thiazolidine-4-carboxylic acid | C15H17NO3S | 详情 | 详情 | |
| (VIII) | 11376 | Pyrrolidine | 123-75-1 | C4H9N | 详情 | 详情 |
Extended Information