1-Methyl-2-tetralone -Drug Synthesis Database

【结构式】

【分子编号】55610

【品名】1-Methyl-2-tetralone

【CA登记号】4024-14-0

【分子式】C₁₁H₁₂O

【分子量】160.21568

【元素组成】C 82.46% H 7.55% O 9.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Friedel-Crafts condensation of 2-phenylpropionyl chloride (I) with ethylene in the presence of AlCl3 furnished 1-methyl-1,2,3,4-tetrahydronaphthalen-2-one (II) (1). Subsequent alkylation of the sodium enolate of (II) with N-(2-chloroethyl)piperidine (III) gave rise to the title compound.

参考文献中间体

合成目标

【1】 Fusco, R.; Tenconi, F. (Pfizer Inc.); Novel 1,2,3,4-tetrahydronaphthalen-2-ones and a process for the preparation thereof. GB 1140990; US 3576811 .
【2】 Tenconi, F.; Furfaro, S.; A process for the preparation of nepinalone. EP 0507001 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	55609	2-phenylpropanoyl chloride		C₉H₉ClO	详情	详情
(II)	55610	1-Methyl-2-tetralone	4024-14-0	C₁₁H₁₂O	详情	详情
(III)	10117	1-(2-Chloroethyl)piperidine; N-(2-Chloroethyl)piperidine	1932-03-2	C₇H₁₄ClN	详情	详情

Extended Information