|
【结 构 式】 
|
【分子编号】55591 【品名】N-(2-hydroxy-1,1-dimethylethyl)-2-oxo-2-phenylacetamide 【CA登记号】 |
【 分 子 式 】C12H15NO3 【 分 子 量 】221.25604 【元素组成】C 65.14% H 6.83% N 6.33% O 21.69% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Phenylglyoxylic acid (III) was converted to the corresponding acid chloride (IV) upon treatment with SOCl2. Subsequent coupling of (IV) with 2-amino-2-methyl-1-propanol (I) afforded amide (V). Reduction of the ketone and amide functions of (V) by means of LiAlH4 furnished the title compound.
| 【1】 Montoro, F.; Calatayud, J.; Luna, M. (Byk Elmu SA); 2-[N-(2-Hydroxy-1,1-dimethylethyl)amino]-1-phenylethanol which is useful, in particular, as an anti-inflammatory, and process for preparing it. CH 670823; FR 2573071; JP 1986143344 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21513 | 2-amino-2-methyl-1-propanol；Karl Fischer;2-Amino-2-methyl-propan-1-ol；2-amino-2-methyl-1-propanol | 124-68-5 | C4H11NO | 详情 | 详情 |
| (III) | 55589 | Benzoylformic acid; Phenylglyoxylic acid | 611-73-4 | C8H6O3 | 详情 | 详情 |
| (IV) | 55590 | 2-oxo-2-phenylacetyl chloride | C8H5ClO2 | 详情 | 详情 | |
| (V) | 55591 | N-(2-hydroxy-1,1-dimethylethyl)-2-oxo-2-phenylacetamide | C12H15NO3 | 详情 | 详情 |
Extended Information