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【结 构 式】 
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【分子编号】55455 【品名】(E)-2-penten-4-yn-1-ol 【CA登记号】5557-88-0 |
【 分 子 式 】C5H6O 【 分 子 量 】82.10204 【元素组成】C 73.15% H 7.37% O 19.49% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The intermediate boronic ester (IV) has been obtained as follows: the silylation of pent-2-en-4-yn-1-ol (I) with Tbdps-Cl and imidazole gives the silyl ether (II), which is condensed with pinacolborane (III) by means of a Rh catalyst tricyclohexyl phosphine and TEA in cyclohexane to afford the target boronic ester intermediate (IV).
| 【1】 Falck, J.R.; Reddy, Y.K.; Asymmetric total synthesis of (+)-fostriecin. Org Lett 2002, 4, 6, 969. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55455 | (E)-2-penten-4-yn-1-ol | 5557-88-0 | C5H6O | 详情 | 详情 |
| (II) | 55456 | tert-butyl(diphenyl)silyl (E)-2-penten-4-ynyl ether; tert-butyl[(E)-2-penten-4-ynyloxy]diphenylsilane | C21H24OSi | 详情 | 详情 | |
| (III) | 55457 | 4,4,5,5-Tetramethyl-1,3,2-dioxaborolane; Pinacolborane | 25015-63-8 | C6H13BO2 | 详情 | 详情 |
| (IV) | 55458 | tert-butyl(diphenyl){[(2E,4Z)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-pentadienyl]oxy}silane; tert-butyl(diphenyl)silyl (2E,4Z)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-pentadienyl ether | C27H37BO3Si | 详情 | 详情 |
Extended Information