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【结 构 式】 
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【分子编号】55380 【品名】N~1~,N~3~-bis{2-[(2-aminoethyl)amino]ethyl}-5-[1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]isophthalamide 【CA登记号】 |
【 分 子 式 】C28H33N7O4 【 分 子 量 】531.6148 【元素组成】C 63.26% H 6.26% N 18.44% O 12.04% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The reaction of 5-aminoisophthalic acid (I) with 1,8-naphthalic anhydride (II) in DMSO/pyridine gives the expected naphthalimide (III), which is condensed with diethylenetriamine (IV) by means of CDI in DMA to yield the isophthalamide (V). Finally, the free amino groups of (V) are condensed with 4-chloronaphthalic anhydride (VI) in pyridine/DMSO to afford the target tris naphthalimide.
| 【1】 Suzuki, K.; Yamada, Y.; Asao, T.; Noguchi, K.; Wakida, M. (Taiho Pharmaceutical Co., Ltd.); Naphthalimidobenzamide derivs.. EP 1020446; US 6300331; WO 0001672 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55377 | 5-Aminobenzene-1,3-dicarboxylic acid; 5-Aminoisophthalic acid; 5-Aminoisophthalmic acid | 99-31-0 | C8H7NO4 | 详情 | 详情 |
| (II) | 16982 | 1H,3H-benzo[de]isochromene-1,3-dione; 1,8-Naphthalic Anhydride | 81-84-5 | C12H6O3 | 详情 | 详情 |
| (III) | 55378 | 5-[1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]isophthalic acid | C20H11NO6 | 详情 | 详情 | |
| (IV) | 55379 | 2,2'-Diaminodiethylamine; 2,2'-Iminodiethylamine; Bis(beta-Aminoethyl)amine; Diethylentriamine; N-(2-Aminoethyl)-1,2-ethanediamine | 111-40-0 | C4H13N3 | 详情 | 详情 |
| (V) | 55380 | N~1~,N~3~-bis{2-[(2-aminoethyl)amino]ethyl}-5-[1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]isophthalamide | C28H33N7O4 | 详情 | 详情 | |
| (VI) | 55381 | 4-Chloro-1,8-naphthalic anhydride | 4053-08-1 | C12H5ClO3 | 详情 | 详情 |
Extended Information