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【结 构 式】

【分子编号】55371

【品名】 

【CA登记号】

【 分 子 式 】C2H6ClO3P

【 分 子 量 】144.494302

【元素组成】C 16.62% H 4.19% Cl 24.54% O 33.22% P 21.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:

The reaction of the already reported amide (VIII) with phosphonate salt (XV) gives the succinimide ammonium salt (XVI), which is finally treated with HCl in acetone to yield the target quaternary ammonium chloride derivative. The phosphonate salt (XV) is obtained by reaction of trimethyl phosphite (XVII) with N-chlorosuccinimide (XVIII) in trimethyl phosphate.

1 Ikemoto, T.; et al.; Convenient efficient synthesis of TAK-779, a nonpeptide CCR5 antagonist: Development of preparation of various ammonium salts using trialkylphosphite and N-halogenosuccinimide. Tetrahedron 2001, 57, 8, 1525.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
55371   C2H6ClO3P 详情 详情
(VIII) 31567 2-(4-methylphenyl)-N-(4-[[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]phenyl)-6,7-dihydro-5H-benzo[a]cycloheptene-8-carboxamide C32H36N2O2 详情 详情
(XV) 55369   C7H13ClNO5P 详情 详情
(XVI) 55370   C37H43N3O4 详情 详情
(XVII) 12642 Trimethyl phosphite 121-45-9 C3H9O3P 详情 详情
(XVIII) 40429 Succinchlorimide; N-Chlorosuccinimide; 1-chloro-2,5-pyrrolidinedione 128-09-6 C4H4ClNO2 详情 详情
Extended Information