　 -Drug Synthesis Database

【结构式】

【分子编号】55371

【品名】　

【CA登记号】

【分子式】C₂H₆ClO₃P

【分子量】144.494302

【元素组成】C 16.62% H 4.19% Cl 24.54% O 33.22% P 21.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：

The reaction of the already reported amide (VIII) with phosphonate salt (XV) gives the succinimide ammonium salt (XVI), which is finally treated with HCl in acetone to yield the target quaternary ammonium chloride derivative. The phosphonate salt (XV) is obtained by reaction of trimethyl phosphite (XVII) with N-chlorosuccinimide (XVIII) in trimethyl phosphate.

参考文献中间体

合成目标

【1】 Ikemoto, T.; et al.; Convenient efficient synthesis of TAK-779, a nonpeptide CCR5 antagonist: Development of preparation of various ammonium salts using trialkylphosphite and N-halogenosuccinimide. Tetrahedron 2001, 57, 8, 1525.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	55371			C₂H₆ClO₃P	详情	详情
(VIII)	31567	2-(4-methylphenyl)-N-(4-[[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl]phenyl)-6,7-dihydro-5H-benzo[a]cycloheptene-8-carboxamide		C₃₂H₃₆N₂O₂	详情	详情
(XV)	55369			C₇H₁₃ClNO₅P	详情	详情
(XVI)	55370			C₃₇H₄₃N₃O₄	详情	详情
(XVII)	12642	Trimethyl phosphite	121-45-9	C₃H₉O₃P	详情	详情
(XVIII)	40429	Succinchlorimide; N-Chlorosuccinimide; 1-chloro-2,5-pyrrolidinedione	128-09-6	C₄H₄ClNO₂	详情	详情

Extended Information