3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropanamide -Drug Synthesis Database

【结构式】

【分子编号】55287

【品名】3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropanamide

【CA登记号】

【分子式】C₂₀H₁₉FN₂O₂

【分子量】338.3815432

【元素组成】C 70.99% H 5.66% F 5.61% N 8.28% O 9.46%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (I) with N,N-dimethyl-2-propenamide (II) by means of LDA in THF gives the addition compound (III), which is then reduced to the target citalopram by means of Red-Al in toluene.

参考文献中间体

合成目标

【1】 Petersen, H. (H. Lundbeck A/S); Method for the preparation of citalopram. WO 0168630 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33233	1-(4-fluorophenyl)-5-phtalancarbonitrile; 1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile		C₁₅H₁₀FNO	详情	详情
(II)	11727	N,N-Dimethylacrylamide; N,N-Dimethyl-2-propenamide	2680-03-7	C₅H₉NO	详情	详情
(III)	55287	3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropanamide		C₂₀H₁₉FN₂O₂	详情	详情

Extended Information