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【结 构 式】 
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【分子编号】55229 【品名】benzyl 2-[(2-benzylacryloyl)amino]acetate 【CA登记号】 |
【 分 子 式 】C19H19NO3 【 分 子 量 】309.3648 【元素组成】C 73.77% H 6.19% N 4.53% O 15.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The reaction of 2-benzylacrylic acid (I) with SOCl2 in hot toluene gives the acyl chloride (II), which is condensed with N-tosylglycine benzyl ester (III) by means of TEA in toluene to yield the corresponding amide (IV). Finally, this compound is condensed with thioacetic acid by heating at 80 C to afford the target acylthio compound.
| 【1】 Schwartz, J.-C.; Lecomte, J.-M.; Duhamel, P.; Duhamel, L.; Danvy, D.; Plaquevent, J.-C.; Monteil, T.; Piettre, S. (Societe Civile Bioprojet); Process for synthesizing N-(mercaptoacyl)amino acid derivs. from alpha-substd. acrylic acids. FR 2816309; US 2002055645 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37279 | 2-benzylacrylic acid | C10H10O2 | 详情 | 详情 | |
| (II) | 55227 | 2-benzylacryloyl chloride | C10H9ClO | 详情 | 详情 | |
| (III) | 55228 | N-p-Tosylglycine benzyl ester | C16H17NO4S | 详情 | 详情 | |
| (IV) | 55229 | benzyl 2-[(2-benzylacryloyl)amino]acetate | C19H19NO3 | 详情 | 详情 | |
| (V) | 12893 | Ethanethioic S-acid | C2H4OS | 详情 | 详情 |
Extended Information