tert-butyl (2R,3S,5R)-2-[(1R,2S)-1-amino-2-methoxy-2-methylpentyl]-5-cyano-3-[(Z)-1-propenyl]-1-pyrrolidinecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】55196

【品名】tert-butyl (2R,3S,5R)-2-[(1R,2S)-1-amino-2-methoxy-2-methylpentyl]-5-cyano-3-[(Z)-1-propenyl]-1-pyrrolidinecarboxylate

【CA登记号】

【分子式】C₂₀H₃₅N₃O₃

【分子量】365.51632

【元素组成】C 65.72% H 9.65% N 11.5% O 13.13%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(LIII)

Acidic cleavage of the chiral sulfinimide group of (LII) provided amine (LIII), which was acylated with Ac2O, yielding acetamide (XXXVII). Finally, hydrolysis and deprotection of (XXXVII) as in Scheme 30409701e gave rise to the title compound.

参考文献中间体

合成目标

【1】 Inhibitors of neuraminidases. WO 0128996 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XXXVII)	55180	tert-butyl (2R,3S,5R)-2-[(1R,2S)-1-(acetylamino)-2-methoxy-2-methylpentyl]-5-cyano-3-[(Z)-1-propenyl]-1-pyrrolidinecarboxylate	C₂₂H₃₇N₃O₄	详情	详情
(LII)	55195	tert-butyl (2R,3S,5R)-5-cyano-2-((1R,2S)-2-methoxy-2-methyl-1-{[(4-methylphenyl)sulfinyl]amino}pentyl)-3-[(Z)-1-propenyl]-1-pyrrolidinecarboxylate	C₂₇H₄₁N₃O₄S	详情	详情
(LIII)	55196	tert-butyl (2R,3S,5R)-2-[(1R,2S)-1-amino-2-methoxy-2-methylpentyl]-5-cyano-3-[(Z)-1-propenyl]-1-pyrrolidinecarboxylate	C₂₀H₃₅N₃O₃	详情	详情

Extended Information