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【结 构 式】 
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【分子编号】54980 【品名】(8S,9S,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate 【CA登记号】 |
【 分 子 式 】C29H40N2O9 【 分 子 量 】560.64468 【元素组成】C 62.13% H 7.19% N 5% O 25.68% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The title compound was prepared by displacement of the 17-methoxy group of geldanamycin (I) with allylamine (II) in chloroform at room temperature.
| 【1】 Schnur, R.C.; et al.; erbB-2 oncogene inhibition by geldanamycin derivatives: Synthesis, mechanism of action, and structure-activity relationships. J Med Chem 1995, 38, 19, 3813. |
| 【2】 Inoue, Y.; Sasaki, K. (Kaken Pharmaceutical Co., Ltd.); Geldanamycin derivs. and antitumor drug. US 4261989 . |
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