N-(2-bromoethyl)-1-phenyl-1-ethanamine; N-(2-bromoethyl)-N-(1-phenylethyl)amine -Drug Synthesis Database

【结构式】

【分子编号】54973

【品名】N-(2-bromoethyl)-1-phenyl-1-ethanamine; N-(2-bromoethyl)-N-(1-phenylethyl)amine

【CA登记号】

【分子式】C₁₀H₁₄BrN

【分子量】228.1319

【元素组成】C 52.65% H 6.19% Br 35.03% N 6.14%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

In a different method, amine (I) was alkylated with 2-bromoethanol (V) to give the N-(hydroxyethyl) amine (VI), which was further converted to bromo amine (VII) by treatment with concentrated HBr. Friedel-Crafts cyclization of (VII) upon heating in the presence of AlCl3 furnished tetrahydroisoquinoline (IV).

参考文献中间体

合成目标

【1】 Lee, Y.N.; Hong, Y.W.; Kim, H.B. (Yuhan Corp.); Process for preparation of pyrmidine derivs.. US 5990311; WO 9742186 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	15148	1-phenylethylamine; DL-a-methylbenzylamine; 1-phenyl-1-ethanamine	618-36-0	C₈H₁₁N	详情	详情
(IV)	54971	1-methyl-1,2,3,4-tetrahydroisoquinoline		C₁₀H₁₃N	详情	详情
(V)	10059	Ethylene bromohydrin; 2-Bromo-1-ethanol	540-51-2	C₂H₅BrO	详情	详情
(VI)	54972	2-[(1-phenylethyl)amino]-1-ethanol		C₁₀H₁₅NO	详情	详情
(VII)	54973	N-(2-bromoethyl)-1-phenyl-1-ethanamine; N-(2-bromoethyl)-N-(1-phenylethyl)amine		C₁₀H₁₄BrN	详情	详情

Extended Information