|
【结 构 式】 
|
【分子编号】54932 【品名】1-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazine; bis(4-fluorophenyl)methyl 2-(1-piperazinyl)ethyl ether 【CA登记号】 |
【 分 子 式 】C19H22F2N2O 【 分 子 量 】332.3933664 【元素组成】C 68.66% H 6.67% F 11.43% N 8.43% O 4.81% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Condensation of bis(4-fluorophenyl)methyl 2-chloroethyl ether (I) with piperazine (II) in refluxing toluene afforded the monosubstituted piperazine (III). This was then alkylated with (3-bromopropyl)benzene (IV) in boiling EtOH to furnish the title compound.
| 【1】 Gootjes, J. (Gist-Brocades NV); Piperazine derivs., process for their preparation and their use. DE 2755752; US 4202896 . |
| 【2】 Van der Zee, P.; et al.; Aryl 1,4-dialk(en)ylpiperazines as selective and very potent inhibitors of dopamine uptake. Eur J Med Chem 1980, 15, 4, 363. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 54931 | 1-[(2-chloroethoxy)(4-fluorophenyl)methyl]-4-fluorobenzene; bis(4-fluorophenyl)methyl 2-chloroethyl ether | C15H13ClF2O | 详情 | 详情 | |
| (II) | 10355 | Diethylenediamine; Piperazine | 110-85-0 | C4H10N2 | 详情 | 详情 |
| (III) | 54932 | 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazine; bis(4-fluorophenyl)methyl 2-(1-piperazinyl)ethyl ether | C19H22F2N2O | 详情 | 详情 | |
| (IV) | 20884 | 1-(3-bromopropyl)benzene | 637-59-2 | C9H11Br | 详情 | 详情 |
Extended Information