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【结 构 式】 
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【分子编号】54813 【品名】3-[(tert-butoxycarbonyl)(methyl)amino]propyl methanesulfonate 【CA登记号】 |
【 分 子 式 】C10H21NO5S 【 分 子 量 】267.34648 【元素组成】C 44.93% H 7.92% N 5.24% O 29.92% S 11.99% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The intermediate 1-substituted imidazopyridine (III) was prepared by several procedures. Alkylation of imidazo[4,5-b]pyridine (I) with mesylate (II) in the presence of NaH provided a mixture of the desired compound (III) and its 3-substituted regioisomer (IV), which were separated by column chromatography.
| 【1】 Itani, H.; et al.; S-3578, a new broad spectrum parenteral cephalosporin exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa synthesis and structure-activity relationships. 22nd Symp Med Chem (Nov 27 2002, Shizuoka) 2002, Abst 1P-16. |
| 【2】 Miwa, H.; Yoshida, T.; Shimada, J.; Kuwahara, S.; Nishitani, Y.; S-3578, a new broad-spectrum cephalosporin: I. Synthesis and structure-activity relationships. 41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001, Chicago) 2001, Abst F-370. |
| 【3】 Itani, H.; Nishitani, Y.; Irie, T. (Shionogi & Co. Ltd.); Imidazo[4,5-b]pyridiniummethyl-containing cephem cpds. having broad antibacterial spectrum. EP 1134222; WO 0032606 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 44867 | 1H-imidazo[4,5-b]pyridine | C6H5N3 | 详情 | 详情 | |
| (II) | 54813 | 3-[(tert-butoxycarbonyl)(methyl)amino]propyl methanesulfonate | C10H21NO5S | 详情 | 详情 | |
| (III) | 54814 | tert-butyl 3-(1H-imidazo[4,5-b]pyridin-1-yl)propyl(methyl)carbamate | C15H22N4O2 | 详情 | 详情 | |
| (IV) | 54815 | tert-butyl 3-(3H-imidazo[4,5-b]pyridin-3-yl)propyl(methyl)carbamate | C15H22N4O2 | 详情 | 详情 |
Extended Information