N-[(3R,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl]-2,5-dibromo-4-fluorobenzamide -Drug Synthesis Database

【结构式】

【分子编号】54690

【品名】N-[(3R,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl]-2,5-dibromo-4-fluorobenzamide

【CA登记号】

【分子式】C₂₀H₁₈Br₂FNO₄

【分子量】515.1736632

【元素组成】C 46.63% H 3.52% Br 31.02% F 3.69% N 2.72% O 12.42%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Compound is synthesized by hydrogenolytic debromination of (3R,4S)-N-(6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-2,5-dibromo-4-fluorobenzamide (I) by means of tritium gas over Pd/C in DMF.

参考文献中间体

合成目标

【1】 Herdon, H.J.; Jerman, J.C.; Chan, W.N. (GlaxoSmithKline plc); Novel receptor. JP 1998511083; US 5985334; WO 9618650 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	54690	N-[(3R,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl]-2,5-dibromo-4-fluorobenzamide		C₂₀H₁₈Br₂FNO₄	详情	详情

Extended Information