2,2-dimethyl-2H-chromene-6-sulfinic acid -Drug Synthesis Database

【结构式】

【分子编号】54657

【品名】2,2-dimethyl-2H-chromene-6-sulfinic acid

【CA登记号】

【分子式】C₁₁H₁₂O₃S

【分子量】224.28048

【元素组成】C 58.91% H 5.39% O 21.4% S 14.3%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Lithiation of 6-bromo-2,2-dimethyl-2H-1-benzopyran (I), followed by treatment with sulfur dioxide, gave the sulfinic acid (II), which was subsequently chlorinated to sulfonyl chloride (III) employing SO2Cl2. Condensation of sulfonyl chloride (III) with aniline furnished the target N-phenyl sulfonamide (IV).

参考文献中间体

合成目标

【1】 Manley, P.W. (Novartis AG; Novartis Deutschland GmbH); Benzopyrans and pharmaceutical compsns. containing them. EP 0828733; JP 1999505820; US 5905156; WO 9637490 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	34890	6-bromo-2,2-dimethyl-2H-chromene	C₁₁H₁₁BrO	详情	详情
(II)	54657	2,2-dimethyl-2H-chromene-6-sulfinic acid	C₁₁H₁₂O₃S	详情	详情
(III)	34892	2,2-dimethyl-2H-chromene-6-sulfonyl chloride	C₁₁H₁₁ClO₃S	详情	详情
(IV)	54658	2,2-dimethyl-N-phenyl-2H-chromene-6-sulfonamide	C₁₇H₁₇NO₃S	详情	详情

Extended Information